Approach
Our Approach
Our proprietary toolkit is rapidly customizable to address new threats
Candidates can be developed within weeks after a virus emerges.
IDENTIFY FUSION REGIONS
Determine the relevant regions of the viral envelope protein.
GENERATE CANDIDATES
Synthesize proprietary lipopeptides and evaluate potency against the threat.
SELECT AND ADVANCE
Advance the optimal candidate into production.
Mechanism of Action:
Fusion Inhibition
de Vries RD, et al. Science. 2021; 371(6536): 1379-1382.
Publications
Tara C. Marcinik, Thomas Kicmal...Matteo Porotto, Amédée des Georges, and Anne Moscona Intermediates in SARS-CoV-2 spike–mediated cell entry. Science Advances. 2022
Katharina S Schmitz, Daryl Greers, Rory D de Vries...Matteo Porotto, Rik L de Swart, and Anne Moscona Potency of Fusion-Inhibitory Lipopeptides against SARS-CoV-2 Variants of Concern. mBio 2022
Olivier Reynard, Claudia Gonzalez...Anne Moscona, Laurent Vecellio, Matteo Porotto, and Branka Horvat Nebulized fusion inhibitory peptide protects cynomolgus macaques from measles virus infection. Nature Communications. 2022
Rory D de Vries, Katharina S. Schmitz...Anne Moscona, and Matteo Porotto Intranasal fusion inhibitory lipopeptide prevents direct-contact SARS-CoV-2 transmission in ferrets. Science. 2021
Victor K. Outlaw, Francesca T. Bovier...Anne Moscona, and Matteo Porotto Inhibition of Coronavirus Entry In Vitro and Ex Vivo by a Lipid-Conjugated Peptide Derived from the SARS-CoV-2 Spike Glycoprotein HRC Domain. mBio. 2020
Katharina S Schmitz, Daryl Greers, Rory D de Vries...Matteo Porotto, Rik L de Swart, and Anne Moscona Potency of Fusion-Inhibitory Lipopeptides against SARS-CoV-2 Variants of Concern. mBio 2022
Olivier Reynard, Claudia Gonzalez...Anne Moscona, Laurent Vecellio, Matteo Porotto, and Branka Horvat Nebulized fusion inhibitory peptide protects cynomolgus macaques from measles virus infection. Nature Communications. 2022
Rory D de Vries, Katharina S. Schmitz...Anne Moscona, and Matteo Porotto Intranasal fusion inhibitory lipopeptide prevents direct-contact SARS-CoV-2 transmission in ferrets. Science. 2021
Victor K. Outlaw, Francesca T. Bovier...Anne Moscona, and Matteo Porotto Inhibition of Coronavirus Entry In Vitro and Ex Vivo by a Lipid-Conjugated Peptide Derived from the SARS-CoV-2 Spike Glycoprotein HRC Domain. mBio. 2020
